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Home > Ethnomedicines and Ethnomedicinal Phytophores Agai
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Blog - Ethnomedicines and Ethnomedicinal Phytophores Against Herpes Viruses
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Last Updated 2008
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Herpes viruses are important human pathogens that can cause mild to severe lifelong infections with high morbidity in susceptible adults. Moreover, Herpes simplex virus (HSV) type 2, for example, has been reported to be responsible for increased transmission and disease progression of human immunodeficiency virus (HIV). Therefore, the discovery of novel anti-HSV drugs deserves great efforts. Herbal medicinal products have been used as source of putative candidate drugs in many diseases. However, in case of viral diseases the development of antivirals from natural sources is less explored probably because within the virus there are few specific targets where the small molecules can interact to inhibit or kill the virus. The currently available antiherpes drugs often lead to the development of viral resistance coupled with the problem of side effects, recurrence and viral latency. However a wide array of herbal products, used by diverse medicinal systems throughout the world, showed high level of anti-herpes virus activities and many of them have complementary and overlapping mechanism of action, either by inhibiting viral replication, or viral genome synthesis. This chapter will summarize some of the promising herbal extracts and purified compounds isolated from the herbal sources by several laboratories. Cases with proven in vitro and documented in vivo activities, along with their structure-activity relationship against herpes viruses are discussed.
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Posted by D. Chattopadhyay and MT. Khan on 2008
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